{"id":442,"date":"2025-09-25T05:06:54","date_gmt":"2025-09-25T05:06:54","guid":{"rendered":"https:\/\/blog.adlington.fr\/index.php\/2025\/09\/25\/huntingtons-disease-successfully-treated-for-first-time\/"},"modified":"2025-09-25T05:06:54","modified_gmt":"2025-09-25T05:06:54","slug":"huntingtons-disease-successfully-treated-for-first-time","status":"publish","type":"post","link":"https:\/\/blog.adlington.fr\/index.php\/2025\/09\/25\/huntingtons-disease-successfully-treated-for-first-time\/","title":{"rendered":"Huntington&#8217;s disease successfully treated for first time"},"content":{"rendered":"<blockquote><p>It starts with a safe virus that has been altered to contain a specially designed sequence of DNA.<br \/>\nThis is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions &#8211; the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery.<br \/>\nThe virus then acts like a microscopic postman \u2013 delivering the new piece of DNA inside brain cells, where it becomes active.<br \/>\nThis turns the neurons into a factory for making the therapy to avert their own death.<br \/>\nThe cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells&#8217; DNA for building mutant huntingtin.<br \/>\n\u2014 Read on <a href=\"https:\/\/www.bbc.com\/news\/articles\/cevz13xkxpro\">www.bbc.com\/news\/articles\/cevz13xkxpro<\/a><\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions &#8211; the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-442","post","type-post","status-publish","format-standard","hentry","category-blog"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/posts\/442","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/comments?post=442"}],"version-history":[{"count":0,"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/posts\/442\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/media?parent=442"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/categories?post=442"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.adlington.fr\/index.php\/wp-json\/wp\/v2\/tags?post=442"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}