Category: Blog

Recent progress in genetics has developed polygenic predictors of complex human traits, including risk for many important complex diseases[10][11] that are typically affected by many genetic variants, each of which confers a small effect on overall risk.[12][13] In a polygenic risk predictor the lifetime (or age-range) risk for the disease is a numerical function captured…

This is the first time I’ve seen prompts arranged in a “playbooks” pattern like this. What a weird and interesting way to write software! — Read on simonwillison.net/2025/Mar/13/xata-agent/

America has been berserk for as long as—Philip Roth: “the indigenous American berserk.” Now we have social media, and it’s more visible than it was before. Not only is it surfaced but it’s encouraged because it’s the business model, right? Extremism, outrage, performance—all of this is now how you make money, not just how you…

I’ve been getting great results out of LLMs for code for over two years now. Here’s my attempt at transferring some of that experience and intution to you. — Read on simonwillison.net/2025/Mar/11/using-llms-for-code/

Lyme disease, like any other medical condition, has a large subjective element and diagnosis is as much an art as a science. Physicians have been cognisant of this paradox since the time of Hippocrates – indeed, the history of medicine can be seen as an effort to put diagnosis on a sounder scientific footing by…

the brothers were descended from the Broccolis of Carrera, who first crossed two Italian vegetables, cauliflower and rabe, to produce the dark green, thick-stalked vegetable that took their name and eventually supported them in the United States. — Read on daringfireball.net/linked/2025/03/08/broccoli-the-man-and-vegetable-behind-the-bond-franchise

Stoicism offers excellent coping strategies in the face of adversity—useful in an industry where most start-ups fail—but taken to extremes, it can also be a pathway to disengagement from the world and people around you. Ketamine, similarly, can afford its users space between themselves and overwhelming despair, which might help explain how it can treat…

A new exhibition shows how artists from the Polish school of posters reimagined films such as Vertigo and Alien while navigating communist censors — Read on www.theguardian.com/artanddesign/gallery/2025/mar/06/give-it-a-polish-classic-film-posters-with-a-twist-in-pictures

Neat CLI tool built in Rust that can create a single packaged HTML file of a web page plus all of its dependencies. — Read on simonwillison.net/2025/Mar/6/monolith/

It’s hard to reliably package and distribute python command line tools to end users. Users frequently encounter challenges: dependency version conflicts, virtual environment management, needing to install python or a specific version of python, etc. Aider employs uv in a couple of novel ways to streamline the installation process: — Read on aider.chat/2025/01/15/uv.html